Genomic Analyses Lead to Novel Secondary Metabolites
نویسندگان
چکیده
منابع مشابه
Complex genomic rearrangements lead to novel primate gene function.
Orthologous genes that maintain a single-copy status in a broad range of species may indicate a selection against gene duplication. If this is the case, then duplicates of such genes that do survive may have escaped the dosage control by rapid and sizable changes in their function. To test this hypothesis and to develop a strategy for the identification of novel gene functions, we have analyzed...
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Secondary metabolites are organic molecules that are not involved in the normal growth and development of an organism. While primary metabolites have a key role in survive of the species, playing an active function in the photosynthesis and respiration, absence of secondary metabolites does not result in immediate death, but rather in long-term impairment of the organism’s survivability, often ...
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Dra. Mariana Spitz – Rua Paulo César de Andrade 200/402 22221-090 Rio de Janeiro RJ Brasil. E-mail: [email protected] Firearm projectiles have been described, albeit rarely, as a cause of lead toxicity. The usual route of lead exposure is oral ingestion, but toxicity secondary to retained bullet fragments has been well documented. Switz et al. described the first case in 1976 – a bullet wa...
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The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the isolation of the novel phthalimidine derivatives marilines A D (1-4). The absolute configuration of the enantiomeric compounds 1 and 2 was assigned by means of theoretical Circular Dichroism calculations. The skeleton of marilines...
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Introduction The cardiotoxicity of doxorubicin (DOX) and other quinone-containing antitumor anthracyclines has been tentatively attributed to the formation of drug semiquinones which generate superoxide anion and reduce ferritin-bound Fe(III), favoring the release of Fe(II) and its subsequent involvement in free radical reactions. In the present study NADPHand DOX-supplemented cytosolic fractio...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2006
ISSN: 0021-8820,1881-1469
DOI: 10.1038/ja.2006.74